STRESS CONDITIONS MODULATE THE CHROMATIN INTERACTIONS NETWORK IN ARABIDOPSIS


Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.The hydrophobicity of Wnt proteins has complicated their purification and limited their use in basic research and as therapeutics.We describe modular tetravalent antibodies that can recr

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Reporting methodological issues of the mendelian randomization studies in health and medical research: a systematic review

Abstract Background Mendelian randomization (MR) studies using Genetic risk scores (GRS) as an instrumental variable (IV) have increasingly been used to control for unmeasured confounding in observational healthcare databases.However, proper reporting of methodological issues is sparse in these studies.We aimed to review published papers related to

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